Name:

Theme: Coagulation

 

OPTION LIST

 

A	Acute Myeloid Leukaemia	I	Liver Disease
B	Bernard Soulier Syndrome	J	Osler-Weber-Rendu Syndrome
C	Disseminated Intravascular Coagulation	K	Thrombotic Thrombocytopenic Purpura
D	Glanzmann’s Thrombasthenia	L	Scurvy
E	Haemophilia A	M	Vitamin K deficiency
F	Haemophilia B	N	Von Willebrand Disease
G	Haemophilia C	O	Wiskott-Aldrich Syndrome
H	Henoch-Schönlein Purpura	P	Yellow Fever

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. You receive a call from the lab about a patient admitted to ICU with meningococcal septicaemia. His PT and APTT are both prolonged, D-dimer is high, platelet count is low and there were schistocytes on his blood film. You go to the patient and note new bruising on his legs.

 

 

2. A 53 year old barmaid goes to see her GP after her dentist had trouble stopping her bleeding after a tooth extraction. Tests revealed prolonged APTT, a bleeding time of 22 minutes and a platelet count of 300x10⁹/l.

 

 

3. A young Ashkenazic Jewish boy suffered from prolonged bleeding after circumcision. His mother reports a long history of menorrhagia.

 

 

4. A middle aged man is brought into A&E bleeding from a wound on his head. He is unkempt, ataxic and appears to be hallucinating. Clotting screen reveals prolonged APTT and PT but normal TT. His platelet count is 80x10⁹/l.

 

 

5. A 40 year old woman presents to her GP with pallor, fatigue and recent fits. On examination she is noted to be febrile and she has a purpuric rash on her legs that doesn’t blanche under pressure. Her platelet count is 40x10⁹/l – she denies any recent foreign travel.

 

 

ANSWERS

1. C

2. N

3. G

4. I

5. K